MersV1, Main, Exploration, bibRecord, 003B99

Serological detection of attenuated HIV-1 variants with nef gene deletions

Identifieur interne : 003B99 ( Main/Exploration ); précédent : 003B98; suivant : 003C00

Serological detection of attenuated HIV-1 variants with nef gene deletions

Auteurs : A. L. Greenway [Australie] ; J. Mills [Australie] ; D. Rhodes [Australie] ; N. J. Deacon [Australie] ; D. A. Mcphee [Australie]

Source :

AIDS : (London) [ 0269-9370 ] ; 1998.

RBID : Pascal:98-0256362

Descripteurs français

KwdFr :
- Anticorps anti-VIH (sang), Cartographie épitopique, Délétion de séquence (génétique), Délétion de séquence (immunologie), Gènes nef (génétique), Humains, Peptides (synthèse chimique), Produits du gène nef, Produits du gène nef du virus de l'immunodéficience humaine, Protéines recombinantes, Survivants, Sérodiagnostic du SIDA (), Séropositivité VIH (immunologie), Séropositivité VIH (virologie), Test ELISA (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Victoria, Études de cohortes, Études prospectives, Études rétrospectives, Évolution moléculaire.
MESH :
- génétique : Délétion de séquence, Gènes nef, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- immunologie : Délétion de séquence, Séropositivité VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- sang : Anticorps anti-VIH.
- synthèse chimique : Peptides.
- virologie : Séropositivité VIH.
Pascal (Inist)
- Cartographie épitopique, Humains, Produits du gène nef, Produits du gène nef du virus de l'immunodéficience humaine, Protéines recombinantes, SIDA, Survivants, Sérodiagnostic du SIDA, Test ELISA, Victoria, Virus HIV1, Diagnostic, Sérologie, Délétion, Gène, Homme, Australie, Études de cohortes, Études prospectives, Études rétrospectives, Évolution moléculaire.
Wicri :
- geographic : Australie.
- topic : Homme.

English descriptors

KwdEn :
- AIDS, AIDS Serodiagnosis (methods), Australia, Cohort Studies, Deletion, Diagnosis, Enzyme-Linked Immunosorbent Assay (methods), Epitope Mapping, Evolution, Molecular, Gene, Gene Products, nef, Genes, nef (genetics), HIV Antibodies (blood), HIV Seropositivity (immunology), HIV Seropositivity (virology), HIV-1 (genetics), HIV-1 (immunology), HIV-1 virus, Human, Humans, Peptides (chemical synthesis), Prospective Studies, Recombinant Proteins, Retrospective Studies, Sequence Deletion (genetics), Sequence Deletion (immunology), Serology, Survivors, Victoria, nef Gene Products, Human Immunodeficiency Virus.
MESH :
- chemical , blood : HIV Antibodies.
- chemical , chemical synthesis : Peptides.
- chemical : Gene Products, nef, Recombinant Proteins, nef Gene Products, Human Immunodeficiency Virus.
- geographic : Victoria.
- genetics : Genes, nef, HIV-1, Sequence Deletion.
- immunology : HIV Seropositivity, HIV-1, Sequence Deletion.
- methods : AIDS Serodiagnosis, Enzyme-Linked Immunosorbent Assay.
- virology : HIV Seropositivity.
- Cohort Studies, Epitope Mapping, Evolution, Molecular, Humans, Prospective Studies, Retrospective Studies, Survivors.

Abstract

Objective: To investigate whether members of a transfusion-linked cohort (the Sydney Bloodbank Cohort) infected with a net-deleted strain of HIV-1 could be differentiated from individuals infected with wild-type strains of HIV-1 by characterizing the Nef antibody response of cohort members. Design: Retrospective and prospective analysis of the nef gene sequence and the antibody response to Nef peptides in HIV-infected subjects. Methods: Plasma was obtained from all individuals of the Sydney cohort, and from a variety of HlV-1-infected and uninfected controls. Antibodies recognizing full-length recombinant HIV-1_NL43 Nef protein and synthetic peptide analogues were assessed by enzyme-linked immunosorbent assay. Results: All 34 individuals infected with wild-type HIV-1 had antibodies reacting with full-length Nef protein as well as with a series of synthetic peptides (6-23-mers) spanning most of the Nef protein of HIV-1_NL43. Although the HIV-1 quasispecies infecting the Sydney cohort had a consensus deletion of the nef gene corresponding to amino-acids 165-206, HIV-1 strains from individual members of the cohort had additional deletions comprising up to 80% of the nef gene. Members of the cohort had antibodies to peptides homologous to all regions of the Nef protein tested, except for a single peptide (amino-acids 162-177) that lies within the consensus nef deletion for the cohort quasispecies. Conclusion: These data show that nef-deleted strains of HIV-1 can be detected serologically. In the Sydney cohort, detection of antibodies to all regions of Nef tested, except that corresponding to amino-acids 162-177, suggests that observed deletions outside this domain occurred after this virus had infected these subjects and stimulated an immune response. A Nef peptide serological assay may be useful for identifying further examples of individuals infected with nef-deleted, attenuated HIV-1 quasispecies and for assessing the evolution of those variants in vivo.

Affiliations:

Australie

Le document en format XML

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<series><title level="j" type="main">AIDS : (London)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>AIDS Serodiagnosis (methods)</term>
<term>Australia</term>
<term>Cohort Studies</term>
<term>Deletion</term>
<term>Diagnosis</term>
<term>Enzyme-Linked Immunosorbent Assay (methods)</term>
<term>Epitope Mapping</term>
<term>Evolution, Molecular</term>
<term>Gene</term>
<term>Gene Products, nef</term>
<term>Genes, nef (genetics)</term>
<term>HIV Antibodies (blood)</term>
<term>HIV Seropositivity (immunology)</term>
<term>HIV Seropositivity (virology)</term>
<term>HIV-1 (genetics)</term>
<term>HIV-1 (immunology)</term>
<term>HIV-1 virus</term>
<term>Human</term>
<term>Humans</term>
<term>Peptides (chemical synthesis)</term>
<term>Prospective Studies</term>
<term>Recombinant Proteins</term>
<term>Retrospective Studies</term>
<term>Sequence Deletion (genetics)</term>
<term>Sequence Deletion (immunology)</term>
<term>Serology</term>
<term>Survivors</term>
<term>Victoria</term>
<term>nef Gene Products, Human Immunodeficiency Virus</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps anti-VIH (sang)</term>
<term>Cartographie épitopique</term>
<term>Délétion de séquence (génétique)</term>
<term>Délétion de séquence (immunologie)</term>
<term>Gènes nef (génétique)</term>
<term>Humains</term>
<term>Peptides (synthèse chimique)</term>
<term>Produits du gène nef</term>
<term>Produits du gène nef du virus de l'immunodéficience humaine</term>
<term>Protéines recombinantes</term>
<term>Survivants</term>
<term>Sérodiagnostic du SIDA ()</term>
<term>Séropositivité VIH (immunologie)</term>
<term>Séropositivité VIH (virologie)</term>
<term>Test ELISA ()</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term>
<term>Victoria</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
<term>Études rétrospectives</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>HIV Antibodies</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Peptides</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Gene Products, nef</term>
<term>Recombinant Proteins</term>
<term>nef Gene Products, Human Immunodeficiency Virus</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Victoria</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, nef</term>
<term>HIV-1</term>
<term>Sequence Deletion</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Délétion de séquence</term>
<term>Gènes nef</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Délétion de séquence</term>
<term>Séropositivité VIH</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Seropositivity</term>
<term>HIV-1</term>
<term>Sequence Deletion</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>AIDS Serodiagnosis</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps anti-VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Peptides</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Séropositivité VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Seropositivity</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term>
<term>Epitope Mapping</term>
<term>Evolution, Molecular</term>
<term>Humans</term>
<term>Prospective Studies</term>
<term>Retrospective Studies</term>
<term>Survivors</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cartographie épitopique</term>
<term>Humains</term>
<term>Produits du gène nef</term>
<term>Produits du gène nef du virus de l'immunodéficience humaine</term>
<term>Protéines recombinantes</term>
<term>SIDA</term>
<term>Survivants</term>
<term>Sérodiagnostic du SIDA</term>
<term>Test ELISA</term>
<term>Victoria</term>
<term>Virus HIV1</term>
<term>Diagnostic</term>
<term>Sérologie</term>
<term>Délétion</term>
<term>Gène</term>
<term>Homme</term>
<term>Australie</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
<term>Études rétrospectives</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Objective: To investigate whether members of a transfusion-linked cohort (the Sydney Bloodbank Cohort) infected with a net-deleted strain of HIV-1 could be differentiated from individuals infected with wild-type strains of HIV-1 by characterizing the Nef antibody response of cohort members. Design: Retrospective and prospective analysis of the nef gene sequence and the antibody response to Nef peptides in HIV-infected subjects. Methods: Plasma was obtained from all individuals of the Sydney cohort, and from a variety of HlV-1-infected and uninfected controls. Antibodies recognizing full-length recombinant HIV-1<sub>NL43</sub>
 Nef protein and synthetic peptide analogues were assessed by enzyme-linked immunosorbent assay. Results: All 34 individuals infected with wild-type HIV-1 had antibodies reacting with full-length Nef protein as well as with a series of synthetic peptides (6-23-mers) spanning most of the Nef protein of HIV-1<sub>NL43</sub>
. Although the HIV-1 quasispecies infecting the Sydney cohort had a consensus deletion of the nef gene corresponding to amino-acids 165-206, HIV-1 strains from individual members of the cohort had additional deletions comprising up to 80% of the nef gene. Members of the cohort had antibodies to peptides homologous to all regions of the Nef protein tested, except for a single peptide (amino-acids 162-177) that lies within the consensus nef deletion for the cohort quasispecies. Conclusion: These data show that nef-deleted strains of HIV-1 can be detected serologically. In the Sydney cohort, detection of antibodies to all regions of Nef tested, except that corresponding to amino-acids 162-177, suggests that observed deletions outside this domain occurred after this virus had infected these subjects and stimulated an immune response. A Nef peptide serological assay may be useful for identifying further examples of individuals infected with nef-deleted, attenuated HIV-1 quasispecies and for assessing the evolution of those variants in vivo.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Greenway, A L" sort="Greenway, A L" uniqKey="Greenway A" first="A. L." last="Greenway">A. L. Greenway</name>
</noRegion>
<name sortKey="Deacon, N J" sort="Deacon, N J" uniqKey="Deacon N" first="N. J." last="Deacon">N. J. Deacon</name>
<name sortKey="Mcphee, D A" sort="Mcphee, D A" uniqKey="Mcphee D" first="D. A." last="Mcphee">D. A. Mcphee</name>
<name sortKey="Mcphee, D A" sort="Mcphee, D A" uniqKey="Mcphee D" first="D. A." last="Mcphee">D. A. Mcphee</name>
<name sortKey="Mills, J" sort="Mills, J" uniqKey="Mills J" first="J." last="Mills">J. Mills</name>
<name sortKey="Rhodes, D" sort="Rhodes, D" uniqKey="Rhodes D" first="D." last="Rhodes">D. Rhodes</name>
</country>
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Serveur d'exploration MERS

Serological detection of attenuated HIV-1 variants with nef gene deletions

Serological detection of attenuated HIV-1 variants with nef gene deletions

Source :

Descripteurs français

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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